Kinetic Analysis of Double-Strand Break Rejoining Reveals the DNA Reparability of γ-Irradiated Tobacco Cultured Cells
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منابع مشابه
Valproic Acid-Mediated Reduction of DNA Double-Strand Break Reparation Capacity of Irradiated MCF-7 Cells
Introduction H istone deacetylase inhibitors (HDIs), as radiation sensitizing agents, are considered as a novel class of anti-cancer factors, which are studied in various tumor cell-lines. Valproic acid (VPA) is an HDI, which is effectively used in the treatment of epilepsy, migraines, and some particular types of depression. In this study, we evaluated the effects of VPA and ionizing radiatio...
متن کاملvalproic acid-mediated reduction of dna double-strand break reparation capacity of irradiated mcf-7 cells
introduction h istone deacetylase inhibitors (hdis), as radiation sensitizing agents, are considered as a novel class of anti-cancer factors, which are studied in various tumor cell-lines. valproic acid (vpa) is an hdi, which is effectively used in the treatment of epilepsy, migraines, and some particular types of depression. in this study, we evaluated the effects of vpa and ionizing radiatio...
متن کاملNoncomplementary DNA double-strand-break rejoining in bacterial and human cells.
We examined the rejoining of noncomplementary restriction enzyme-produced DNA double-strand breaks in Escherichia coli and in cultured human cells. The enzymes used in this study, ClaI, BamHI and SalI, produce double-strand breaks with 5 protruding single strands. The joining of a ClaI-produced DNA end to a BamHI-produced end or to a SalI-produced end was examined at the DNA sequence level. End...
متن کاملThe study of dose gamma rays of 192Ir source on DNA single strand break (SSB) and DNA double strand break (DSB) in soft tissue phantom
Introduction: Passage of ionizing radiation through the organs of living creatures develops clusters of damaged nucleotides inside the DNA rounds. 192Ir Gamma source is one of the most widely used sources in brachytherapy of cervical and prostate cancer. Thus, in this research, we investigated the flux of photons and its resulting secondary electrons, the single-strand break (S...
متن کاملTwo-lesion kinetic model of double-strand break rejoining and cell killing.
Radiobiological models, such as the lethal and potentially lethal (LPL) model and the repair-misrepair (RMR) model, have been reasonably successful at explaining the cell killing effects of radiation. However, the models have been less successful at relating cell killing to the formation, repair and misrepair of double-strand breaks (DSBs), which are widely accepted as the main type of DNA dama...
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ژورنال
عنوان ژورنال: Journal of Radiation Research
سال: 2009
ISSN: 0449-3060,1349-9157
DOI: 10.1269/jrr.08064